Estimating appropriate tuning paramaters delta and the number of degrees of freedom, N. We assume that dispersion follows Gamma distribution. Appropriate shrinkage is selected based on the MLE of the the difference between fitted dispersion and shrunk dispersion

Estimating appropriate tuning paramaters delta and the number of degrees of freedom, N. We assume that dispersion follows Gamma distribution. Appropriate shrinkage is selected based on the MLE of the the difference between fitted dispersion and shrunk dispersion

Usage

estim_delta(estimates, thetaFilter = NULL)

Arguments

estimates

Data frame from estim_bbparams()

thetaFilter

Optional numeric threshold; genes with bb_theta < thetaFilter are excluded. Genes with dispersion below the set threshold are excluded from the shrinking procedure.

Examples

estim_delta()
#> Error in eval(assertion, env): argument "estimates" is missing, with no default